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Editorial Part I The promise of Precision Medicine Chapter 1 Historical perspectives of individualized Medicine Chapter 2 Societal and Ethical challenges of Precision Medicine Chapter 3 The continuum from mendelian to complex diseases Part II Key drivers to achieve Precision Medicine Chapter 4 The role of biomarkers in PM: opportunities and challenges Chapter 5 Biobanking in Precision Medicine Chapter 6 Laboratory Medicine as a Key Driver in Precision Medicine Chapter 7 The Role of drug monitoring in Precision Medicine Chapter 8 Data sciences and predictive analytics in Precision Medicine Part III From Data to Insights Chapter 9 Radiomics: Bridging Medical imaging and Precision Medicine Chapter 10 The Patient's Journey in Intensive Care Chapter 11 Clinical Informatics Challenges in Precision Medicine Part IV Connecting the dots through panomics Chapter 12 The Human Protein Atlas - implications for human biology, drug development and precision medicine Chapter 13 A multi-omic approach reveals a new type of inherited errors of vitamin B12 metabolism Chapter 14 The genome, the metabolome and beyond

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