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Foreword (Philippe Mauguin) Introduction. Research for pesticide-free agriculture: A disruptive framework today to build tomorrow's solutions (Christian Huyghe, Florence Jacquet, Julia Jouan) Promoting prophylaxis Developing agroecology Mobilising all actors in the agricultural sector References Chapter 1. Overview of pesticide use (Florence Jacquet, Julia Jouan) Crop protection: A historic lever for increasing agricultural production Pesticide use has become a major societal concern From the 1990s to the present day: numerous but not very effective initiatives to reduce pesticide use Conclusion References Chapter 2. Why do we need to change our crop protection strategies? (Florence Jacquet, Julia Jouan) Pesticide dependency in agricultural systems: what are the obstacles to change? IPM and organic agriculture: two dominant strategies for avoiding pesticides but reaching their limits Conclusion References Chapter 3. Agroecological cropping systems to reduce pesticide use (Marie-Hélène Jeuffroy, Rémy Ballot, Anne Merot, Jean-Marc Meynard, Sylvaine Simon) Growing without pesticides requires a radical change in the way agricultural practices are managed Existing agronomic solutions for reducing and eliminating pesticide use Growing without pesticides requires a renewal of working methods and knowledge production for agronomists Conclusion References Chapter 4. Biocontrol(s) from a pesticide-free agricultural perspective (Thibaut Malausa, Aura Parmentier-Cajaiba, Marie-Noëlle Brisset, Manuel Boutet) Biocontrol: a single term for a variety of crop protection methods Dominant agricultural models influence biocontrol practices and research Which research and innovation priorities will be encouraged by the aim for pesticide-free agriculture? The importance of diversifying business models in the biocontrol sector Diagnostic, forecasting and decision support services at the heart of future strategies and biocontrol business models? Conclusion References Chapter 5. Developing species and varieties enabling the redesign of cropping systems (Anne Laperche, Mélanie Jubault, Maria Manzanares-Dauleux, Matthieu Carof, Edith Le Cadre) Introduction What are the challenges for plant breeding in a pesticide-free agricultural context? Avenues for new breeding programmes Integrating new varieties into cropping systems Conclusion References Chapter 6. Mobilising agricultural equipment and digital technology for pesticide-free cropping systems (Xavier Reboud, Laurent Bedoussac, Vincent Cellier, Stéphane Cordeau, Sylvain Delzon, Melen Leclerc, Julia Jouan) Precision, autonomy and adaptability: key themes for agricultural equipment in pesticide-free systems Digital technology for extended epidemiological surveillance Digital technology for sharing, traceability and value enhancement of agricultural production Conclusion References Chapter 7. Political and organisational levers (Pascale Bazoche, Alain Charpentier, Adelaide Fadhuile, Fabienne Femenia, Cédric Gendre, Benoît Grimonprez, Mourad Hannachi, Florence Jacquet, Julia Jouan, Alexandre Sauquet, Julie Subervie, Sophie Thoyer) Agricultural development and training policies: how to provide farmers with the keys to alternative approaches? Regulatory instruments: what role do they play in the regulation of pesticides? Subsidising alternatives to pesticides: how can we improve the effectiveness of agri-environmental measures? Taxation systems: how can we make them acceptable? Food product differentiation: how can we increase the interest in pesticide-free products? Territorial collective dynamics: how can we encourage coordination among stakeholders? Conclusion References General conclusion (Christian Huyghe, Florence Jacquet, Julia Jouan) Pesticide-free as a new paradigm for research Pesticide-free: an international issue that affects all stakeholders in agricultural and agrifood chains Thinking pesticide-free alongside other challenges in sustainable agriculture References Acknowledgements List of authors

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